Sodium fluoride activation of human lymphocyte adenylate cyclase is reduced in old age.
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چکیده
منابع مشابه
Activation and inhibition of fat cell adenylate cyclase by fluoride.
Incubation (30 degrees) of fat cell particulate fractions with fluoride before assay in the effective absence of fluoride results in activation of adenylate cyclase. Whereas the effect of fluoride (1.3 to 7 mM) when added to the assay was maximal in less than 2 min, 10 or 15 min of incubation before assay was usually required to produce maximal activation with any given concentration of fluorid...
متن کاملCalcium-dependent adenylate cyclase from rat cerebral cortex. Reversible activation by sodium fluoride.
The adenylate cyclase activity of a particulate preparation of rat cerebral cortex is comprised of two contributing components, only one of which requires a Ca’+-dependent regulator protein (CDR) for activity. The CDR-dependent component was stabilized by CDR. responded to increasing free Ca’+ concentrations biphasically (activation then inhibition), and was inhibited by high ratios of Mg’+ to ...
متن کاملE VALUATION OF ADENYLATE CYCLASE ACTIVITY IN MITRAL VALVE PROLAPSE
The term mitral valve prolapse (MVP) is used for a particular subset of patients with hyperadrenergic dysautonomia. It occurs when part of a leaflet or both leaflets of the mitral valve extend above the plane of the atrioventricular junction during ventricular systole. The adenylate cyclase activity in MVP dys-autonomia was studied by extraction of enzyme from the erythrocytes from 62 norma...
متن کاملAluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride.
Activation of the purified guanine nucleotide-binding regulatory component (G/F) of adenylate cyclase by F- requires the presence of Mg2+ and another factor. This factor, which contaminates commercial preparations of various nucleotides and disposable glass test tubes, has been identified as Al3+. In the presence of 10 mM Mg2+ and 5 mM F-, AlCl3 causes activation of G/F with an apparent activat...
متن کاملInhibition by fluoride ion of hormonal activation of fat cell adenylate cyclase.
The adenylate cyclase system in a plasma membrane-rich fraction termed “ghosts” from rat adipocytes is activated by epinephrine, adrenocorticotropic hormone, glucagon, and secretin, and is also stimulated in the presence of fluoride ion. Studies of the temperature dependency of activation by these agents showed that whereas hormonal activation occurs down to lo”, activation by fluoride ion is m...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1982
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1982.tb01881.x